The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. It is also on a 30-21 roll on top-rated NFL picks since Week 7 of last season. The model enters Week 15 of the 2023 NFL season on an incredible 176-129 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. All of the Week 15 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 15 NFL picks now. The largest of the NFL Vegas odds this week belongs to the 49ers, who are 12.5-point favorites over the Cardinals in the NFL betting lines. Other games with slim Week 15 NFL spreads include Falcons vs. While Dallas is 0-4 against the spread in its last four games as an underdog, it is also a league-best 32-15 ATS since the start of the 2021 season. ET kickoff according to the latest Week 15 NFL odds. Buffalo is a 2-point home favorite for the 4:25 p.m. It's not too often that a 10-3 team is an underdog to a 7-6 squad, but that's the case in Cowboys vs.